Dr. Sagari Bette trained in Neurology at Beth Israel Deaconess Medical Center / Harvard Medical School and completed her Fellowship in Movement Disorders at the University of Miami Miller School of Medicine Parkinson’s Disease and Movement Disorders Center, a Parkinson’s Foundation Center of Excellence. She completed her undergraduate training at Stanford University and obtained her M.D. degree at University of Texas Southwestern Medical School.
Dr. Richard Dewey III trained in Neurology at the University of Texas Southwestern Medical Center in Dallas, TX and completed his Movement Disorders Fellowship at Southwestern Medical Center in Dallas, TX as well. He has recently joined the Parkinson’s Disease and Movement Disorders Center in Boca Raton, Florida.
Dr. Richard B. Dewey, Jr. recently retired from his position of Professor in the Department of Neurology and Director of the Clinical Center for Movement Disorders at the University of Texas Southwestern Medical Center in Dallas, Texas. He has recently joined the Parkinson’s Disease and Movement Disorders Center in Boca Raton, Florida where he sees mainly new patients who are interested in receiving state of the art care for their movement disorder in a setting where they can participate in cutting-edge clinical trials.
Lisbeth Pennente is a Clinical Research Coordinator and Psychometrician at The Parkinson’s Disease and Movement Disorders Center of Boca Raton. She has over 20 years of experience in clinical research including a wide range of Phase I through Phase IV clinical trials in Parkinson’s Disease, Alzheimer’s Disease, Huntington’s Disease and other Movement Disorders.
PD starts in the brain decades before the onset of symptoms, giving physicians ample time to intervene in an individualized fashion for those at risk. There is no “magic pill” or “magic cure” for PD treatment or prevention; however, combining a variety of strategies over an extended time period based on strong science and safety may yield the best opportunity for successful neuroprotection. First, individuals must be risk stratified based on genetic status and underlying pathogenic mechanism as discerned by biomarker profiling incorporating inflammatory markers, metabolic panels, anthropometrics and peripheral α-synuclein markers. Each genetic etiology has its own distinct preclinical/prodromal motor and nonmotor signs which will be longitudinally monitored (e.g., LRRK2 carriers demonstrate early anxiety, parkinsonian motor signs, gait abnormalities, arm swing asymmetry and spiral drawing variability). Additional longitudinal monitoring of other common motor and non-motor (including cognitive changes, constipation, REM sleep behavior disorder, restless legs syndrome, dandruff) prodromal symptoms of PD will allow for both risk assessment and evaluation of the effectiveness of clinical interventions. Our approach is based on a collaborative care model for PD, while being firmly grounded in the latest scientific evidence-based therapies. This integrated approach to care aims to provide the most comprehensive therapies for patients who are at risk for the disease.
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